Lösemittelfreie Mikrowellen-Synthese: Direct amidation of carboxylic acids with amines under microwave irradiation using silica gel as a solid support
A highly improved and green methodology for the direct amidation of carboxylic acids with amines using silica gel as a solid support and catalyst is described. The scope of this method is exemplified by the use of several aliphatic, aromatic, unsaturated and fatty acids. The reaction is also applied to different primary and secondary amines. […]